BMS-754807

CAT: 1568-C16130Size: 10 mgDry Ice: YesHazardous: No
CAT#:1568-C16130Size:10 mg
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CAS Number
1001350-96-4
SKU
C16130-10mg
Target
C-Met
Applications
Protein Tyrosine Kinase
Smiles
CC1 (CCCN1C2=NN3C=CC=C3C (=N2) NC4=NNC (=C4) C5CC5) C (=O) NC6=CN=C (C=C6) F
Molecular Formula
C23H24FN9O
Additionnal Information
BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
Storage Conditions
2 years -80 in solvent

1001350-96-4

PubChem
cas1001350-96-4
modify2026-05-17
descriptionBMS-754807 is a pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a member of pyrazoles, a member of pyridines, a member of pyrrolidines and a pyrrolotriazine.
synonyms
BMS-7548071001350-96-4BMS 754807BMS754807W9E3353E8JBMS-754807-01
(2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
CHEBI:88339
(2S)-1-{4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
2-PYRROLIDINECARBOXAMIDE, 1-(4-((5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO)PYRROLO(2,1-F)(1,2,4)TRIAZIN-2-YL)-N-(6-FLUORO-3-PYRIDINYL)-2-METHYL-, (2S)-
+ 15 more
PubChem LinkClick here

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