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JY-2

CAT: 1568-C15143-04Size: 1 gDry Ice: NoHazardous: No
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CAT#:1568-C15143-04Size:1 g
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CAS Number
339103-05-8
SKU
C15143-5mg
Target
FOX
Applications
Metabolism
Molecular Formula
C13H7Cl2N3O
Additionnal Information
JY-2 is a selective and orally active inhibitor of the transcription factor forkhead box O1 (FoxO1) . JY-2 suppresses FoxO1-driven transcriptional activity with an IC50 of 22 μM, and also exerts moderate inhibitory effects on FoxO3a and FoxO4. JY-2 also exhibits anti-diabetic properties.

Chemical Information

2-[5-(2,4-Dichlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine
CAS Number339103-05-8
PubChem CID702923
IUPAC Name5-(2,4-dichlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole
Molecular FormulaC13H7Cl2N3O
Molecular Weight292.12
XLogP3.3
Topological Polar Surface Area51.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity308
SMILES
C1=CC=NC(=C1)C2=NOC(=N2)C3=C(C=C(C=C3)Cl)Cl
InChI
InChI=1S/C13H7Cl2N3O/c14-8-4-5-9(10(15)7-8)13-17-12(18-19-13)11-3-1-2-6-16-11/h1-7H
InChIKey
WBMHQMQALJDGHI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[5-(2,4-Dichlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine
CAS: 339103-05-8
CID: 702923
Formula: C13H7Cl2N3O
MW: 292.12
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.12
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass290.9966172
Monoisotopic Mass290.9966172
Topological Polar Surface Area51.8 Ų
Heavy Atom Count19
Formal Charge0
Complexity308
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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