Indisulam

CAT: 1568-C14457-02Size: 10 mM / 1 mLDry Ice: NoHazardous: No

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CAT#:1568-C14457-02Size:10 mM / 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

165668-41-7

Synonyms

E7070

SKU

C14457-5mg

Target

Carbonic Anhydrase

Applications

Metabolism

Smiles

N[S] (=O) (=O) C1=CC=C (C=C1) [S] (=O) (=O) NC2=C3[NH]C=C (Cl) C3=CC=C2

Molecular Formula

C14H12ClN3O4S2

Additionnal Information

Indisulam (E7070), a sulfonamide anticancer agent, is a potent carbonic anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.

Storage Conditions

3 years -20°C powder

Chemical Information

Indisulam

Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a sulfonamide, an organochlorine compound and a chloroindole.

CAS Number	165668-41-7
PubChem CID	216468
IUPAC Name	4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
Molecular Formula	C14H12ClN3O4S2
Molecular Weight	385.8
XLogP	1.8
Topological Polar Surface Area	139
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	24
Formal Charge	0
Complexity	650

SMILES

C1=CC2=C(C(=C1)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N)NC=C2Cl

InChI

InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)

InChIKey

SETFNECMODOHTO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 165668-41-7

CID: 216468

Formula: C14H12ClN3O4S2

MW: 385.8

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	385.8
XLogP3	1.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	384.9957759
Monoisotopic Mass	384.9957759
Topological Polar Surface Area	139 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	650
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA7206-5.1	Indisulam
HY-13650R-01	Indisulam (Standard)
MBS384660-01	Indisulam (E7070)

Indisulam

Chemical Information

Alternative Products

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