Indisulam (Standard)

CAT: 0804-HY-13650R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13650R-01Size:5 mg
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Description
Indisulam (Standard) is the analytical standard of Indisulam. This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15[1][2].
CAS Number
[165668-41-7]
UNSPSC
12352100
Target
Carbonic Anhydrase; Molecular Glues; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others; PROTAC
Field of Research
Cancer
Smiles
O=S(C1=CC=C(S(=O)(N)=O)C=C1)(NC2=CC=CC3=C2NC=C3Cl)=O
Molecular Formula
C14H12ClN3O4S2
Molecular Weight
385.85
References & Citations
[1]Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37 (17) :2275-82.|[2]Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14 (1) :217-23.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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