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PLX5622

CAT: 1568-C13739-02Size: 10 mM / 1 mLDry Ice: NoHazardous: No
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CAT#:1568-C13739-02Size:10 mM / 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1303420-67-8
SKU
C13739-2mg
Target
CSF-1R
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC2=C (NC=C2CC3=C (N=C (C=C3) NCC4=C (N=CC (=C4) F) OC) F) N=C1
Molecular Formula
C21H19F2N5O
Additionnal Information
PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3.
Storage Conditions
3 years -20°C powder

Chemical Information

Plx-5622

PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor. PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is mostly used in the way of feed free diet.

CAS Number1303420-67-8
PubChem CID52936034
IUPAC Name6-fluoro-N-[(5-fluoro-2-methoxy-3-pyridinyl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine
Molecular FormulaC21H19F2N5O
Molecular Weight395.4
XLogP4.1
Topological Polar Surface Area75.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity529
SMILES
CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1
InChI
InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26)
InChIKey
NSMOZFXKTHCPTQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Plx-5622
CAS: 1303420-67-8
CID: 52936034
Formula: C21H19F2N5O
MW: 395.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight395.4
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass395.15576657
Monoisotopic Mass395.15576657
Topological Polar Surface Area75.7 Ų
Heavy Atom Count29
Formal Charge0
Complexity529
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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