Inavolisib (GDC-0077)

• CAS Number :

  2060571-02-8

• Synonyms :

  RG6114, RO-7113755

• SKU :

  C13576-5mg

• Target :

  PI3K

• Applications :

  PI3K/Akt/mTOR

• Smiles :

  CC (C (=O) N) NC1=CC2=C (C=C1) C3=NC (=CN3CCO2) N4C (COC4=O) C (F) F

• Molecular Formula :

  C18H19F2N5O4

• Additionnal Information :

  Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.

• Storage Conditions :

  3 years -20°C powder