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WNK463

CAT: 1568-C13365-02Size: 10 mM / 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C13365-02Size:10 mM / 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2012607-27-9
SKU
C13365-5mg
Target
Serine/threonin kinase
Applications
Cell Cycle
Smiles
CC (C) (C) NC (=O) C1=CN=CN1C2CCN (CC2) C3=NC=C (C=C3) C4=NN=C (O4) C (F) (F) F
Molecular Formula
C21H24F3N7O2
Additionnal Information
WNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4) with IC50 of 5nM, 1nM, 6nM, and 9nM.
Storage Conditions
2 years -80 in solvent

Chemical Information

N-Tert-Butyl-1-(1-{5-[5-(Trifluoromethyl)-1,3,4-Oxadiazol-2-Yl]pyridin-2-Yl}piperidin-4-Yl)-1h-Imidazole-5-Carboxamide
CAS Number2012607-27-9
PubChem CID121487936
IUPAC NameN-tert-butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]piperidin-4-yl]imidazole-4-carboxamide
Molecular FormulaC21H24F3N7O2
Molecular Weight463.5
XLogP2.6
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity682
SMILES
CC(C)(C)NC(=O)C1=CN=CN1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F
InChI
InChI=1S/C21H24F3N7O2/c1-20(2,3)27-17(32)15-11-25-12-31(15)14-6-8-30(9-7-14)16-5-4-13(10-26-16)18-28-29-19(33-18)21(22,23)24/h4-5,10-12,14H,6-9H2,1-3H3,(H,27,32)
InChIKey
HWSHOMMVLGBIDN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Tert-Butyl-1-(1-{5-[5-(Trifluoromethyl)-1,3,4-Oxadiazol-2-Yl]pyridin-2-Yl}piperidin-4-Yl)-1h-Imidazole-5-Carboxamide
CAS: 2012607-27-9
CID: 121487936
Formula: C21H24F3N7O2
MW: 463.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight463.5
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass463.19435752
Monoisotopic Mass463.19435752
Topological Polar Surface Area102 Ų
Heavy Atom Count33
Formal Charge0
Complexity682
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19168257-01WNK463
BW164081-01WNK463 monohydrate
A16205-25WNK463 25mg
A16205-5WNK463 5mg
A16205-100WNK463 100mg
A16205-50WNK463 50mg
A16205-10WNK463 10mg

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