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Voruciclib

CAT: 1568-C13235Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C13235Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1000023-04-0
Synonyms
P1446A-05
SKU
C13235-5mg
Target
CDK
Applications
Cell Cycle
Molecular Formula
C22H19ClF3NO5
Additionnal Information
Voruciclib (P1446A-05) is a small molecule flavone derivative, a pan inhibitor of CDK with Ki's of 0.626 nM-9.1nM, that potently targets CDK9, represses expression of MCL-1 and leads to tumor cell apoptosis and tumor growth inhibition in multiple models of diffuse large B-cell lymphoma (DLBCL) .

1000023-04-0

PubChem
cas1000023-04-0
modify2026-05-17
descriptionVoruciclib is under investigation in clinical trial NCT03547115 (A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML).
synonyms
Voruciclib1000023-04-0
2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
P1446A-05W66XP666AM
2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one
P-1446
2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl)-
voruciclibum+ 15 more
PubChem LinkClick here

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