KN-62

CAT: 1568-C12674-02Size: 10 mM / 1 mLDry Ice: YesHazardous: No

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CAT#:1568-C12674-02Size:10 mM / 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

127191-97-3

SKU

C12674-5mg

Target

CaMK

Applications

Neuronal Signaling

Smiles

CN (C (CC1=CC=C (C=C1) OS (=O) (=O) C2=CC=CC3=C2C=CN=C3) C (=O) N4CCN (CC4) C5=CC=CC=C5) S (=O) (=O) C6=CC=CC7=C6C=CN=C7

Molecular Formula

C38H35N5O6S2

Additionnal Information

KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM) . It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.

Storage Conditions

2 years -80 in solvent

Chemical Information

4-((2S)-2-((5-Isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl 5-isoquinolinesulfonate

5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.

CAS Number	127191-97-3
PubChem CID	5312126
IUPAC Name	[4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate
Molecular Formula	C38H35N5O6S2
Molecular Weight	721.8
XLogP	5.6
Topological Polar Surface Area	147
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Heavy Atom Count	51
Formal Charge	0
Complexity	1370

SMILES

CN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7

InChI

InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

InChIKey

RJVLFQBBRSMWHX-DHUJRADRSA-N

Chemical Structure

2D Structure

CAS: 127191-97-3

CID: 5312126

Formula: C38H35N5O6S2

MW: 721.8

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	721.8
XLogP3	5.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Exact Mass	721.20287620
Monoisotopic Mass	721.20287620
Topological Polar Surface Area	147 Å²
Heavy Atom Count	51
Formal Charge	0
Complexity	1370
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
C12209-01	KN-93
C12209-5mg	KN-93
C12209-10mM/1mL	KN-93
C12209-25mg	KN-93
C11957-01	KN-92 phosphate
C12675-01	KN-93 Phosphate
C12675-10mM/1mL	KN-93 Phosphate
C12675-200mg	KN-93 Phosphate
C11957-2mg	KN-92 phosphate
C12675-50mg	KN-93 Phosphate

Alternative Products

Catalog	Name
255606	KN-62
FB24811-01	KN 62

KN-62

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