AMG-9810

• CAS Number :

  545395-94-6

• SKU :

  C12328-5mg

• Target :

  TRP Channel

• Applications :

  Neuronal Signaling

• Smiles :

  CC (C) (C) C1=CC=C (/C=C/C (=O) NC2=CC=C3OCCOC3=C2) C=C1

• Molecular Formula :

  C21H23NO3

• Additionnal Information :

  AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.

• Storage Conditions :

  3 years -20°C powder