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ETC-159

CAT: 1568-C12058-02Size: 10 mM / 1 mLDry Ice: NoHazardous: No
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CAT#:1568-C12058-02Size:10 mM / 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1638250-96-0
Synonyms
ETC-1922159
SKU
C12058-5mg
Target
PORCN
Applications
Cytoskeletal Signaling
Smiles
CN1C2=C (C (=O) N (C1=O) C) N (C=N2) CC (=O) NC3=NN=C (C=C3) C4=CC=CC=C4
Molecular Formula
C19H17N7O3
Additionnal Information
ETC-159 (ETC-1922159) is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.
Storage Conditions
3 years -20°C powder

Chemical Information

Etc-159

Porcupine Inhibitor ETC-159 is an orally bioavailable inhibitor of the membrane-bound O-acyltransferase (MBOAT) porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, ETC-159 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational palmitoylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine catalyzes the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion. Wnt signaling is dysregulated in a variety of cancers.

CAS Number1638250-96-0
PubChem CID86280523
IUPAC Name2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
Molecular FormulaC19H17N7O3
Molecular Weight391.4
XLogP0.5
Topological Polar Surface Area113
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity654
SMILES
CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)NC3=NN=C(C=C3)C4=CC=CC=C4
InChI
InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
InChIKey
QTRXIFVSTWXRJJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Etc-159
CAS: 1638250-96-0
CID: 86280523
Formula: C19H17N7O3
MW: 391.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.4
XLogP30.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass391.13928743
Monoisotopic Mass391.13928743
Topological Polar Surface Area113 Ų
Heavy Atom Count29
Formal Charge0
Complexity654
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA9073-100ETC-159
A15840-50ETC-159 50mg
A15840-10ETC-159 10mg
A15840-5ETC-159 5mg

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