LY2109761

CAT: 1568-C08795-01Size: 5 mgDry Ice: YesHazardous: No

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CAT#:1568-C08795-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

700874-71-1

SKU

C08795-5mg

Target

TGF-beta/Smad

Applications

TGF-beta/Smad

Smiles

C1CC2=C (C (=NN2C1) C3=CC=CC=N3) C4=C5C=CC (=CC5=NC=C4) OCCN6CCOCC6

Molecular Formula

C26H27N5O2

Additionnal Information

LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis.

Storage Conditions

2 years -80 in solvent

Chemical Information

LY2109761

a transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

CAS Number	700874-71-1
PubChem CID	11655119
IUPAC Name	4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine
Molecular Formula	C26H27N5O2
Molecular Weight	441.5
XLogP	2.8
Topological Polar Surface Area	65.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Heavy Atom Count	33
Formal Charge	0
Complexity	632

SMILES

C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6

InChI

InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2

InChIKey

IHLVSLOZUHKNMQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 700874-71-1

CID: 11655119

Formula: C26H27N5O2

MW: 441.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	441.5
XLogP3	2.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	441.21647512
Monoisotopic Mass	441.21647512
Topological Polar Surface Area	65.3 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	632
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS3605686-01	LY2109761
A11133-5	LY2109761 5mg
HY-12075R-01	LY2109761 (Standard)
A11133-200	LY2109761 200mg
A11133-100	LY2109761 100mg
A11133-50	LY2109761 50mg

LY2109761

Chemical Information

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