RN-1734

• CAS Number :

  946387-07-1

• Synonyms :

  TRPV4 Antagonist I

• SKU :

  C08751-5mg

• Target :

  TRP Channel

• Applications :

  Neuronal Signaling

• Smiles :

  CC (C) NCCN (C (C) C) S (=O) (=O) C1=C (C=C (C=C1) Cl) Cl

• Molecular Formula :

  C14H22Cl2N2O2S

• Additionnal Information :

  RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.

• Storage Conditions :

  3 years -20°C powder