PF-4708671

• CAS Number :

  1255517-76-0

• SKU :

  C08325-50mg

• Target :

  S6 Kinase

• Applications :

  MAPK

• Smiles :

  CCC1=CN=CN=C1N2CCN (CC2) CC3=NC4=C (N3) C=C (C=C4) C (F) (F) F

• Molecular Formula :

  C19H21F3N6

• Additionnal Information :

  PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.

• Storage Conditions :

  2 years -80 in solvent