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LY294002

CAT: 1568-C07522-02Size: 10 mM / 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C07522-02Size:10 mM / 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
154447-36-6
Synonyms
SF 1101, NSC 697286
SKU
C07522-10mg
Target
Autophagy
Applications
Autophagy
Smiles
C1COCCN1C2=CC (=O) C3=C (O2) C (=CC=C3) C4=CC=CC=C4
Molecular Formula
C19H17NO3
Additionnal Information
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
Storage Conditions
2 years -80 in solvent

Chemical Information

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

LY294002 is a chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. It has a role as a geroprotector, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an autophagy inhibitor. It is a member of chromones, an organochlorine compound and a member of morpholines.

CAS Number154447-36-6
PubChem CID3973
IUPAC Name2-morpholin-4-yl-8-phenylchromen-4-one
Molecular FormulaC19H17NO3
Molecular Weight307.3
XLogP3.1
Topological Polar Surface Area38.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity463
SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
InChI
InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey
CZQHHVNHHHRRDU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
CAS: 154447-36-6
CID: 3973
Formula: C19H17NO3
MW: 307.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight307.3
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass307.12084340
Monoisotopic Mass307.12084340
Topological Polar Surface Area38.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity463
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-10108-01LY294002
A10547-10LY294002 10mg
E5875-1gLY294002 hydrochloride
HY-10108A-01LY294002 (hydrochloride)
1747-5EZSolution™ LY294002

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