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LY294002

CAT: 0931-T2008-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T2008-05Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
154447-36-6
Target
Autophagy, Apoptosis, Casein Kinase, DNA-PK, PI3K
Related Pathways
Stem Cells, PI3K/Akt/mTOR signaling, Apoptosis, Autophagy, Metabolism, DNA Damage/DNA Repair
Purity
0.9996
Bioactivity
LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM) . LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM) . LY294002 activates apoptosis and autophagy.
Smiles
O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Molecular Formula
C19H17NO3
Molecular Weight
307.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

LY294002 is a chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. It has a role as a geroprotector, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an autophagy inhibitor. It is a member of chromones, an organochlorine compound and a member of morpholines.

CAS Number154447-36-6
PubChem CID3973
IUPAC Name2-morpholin-4-yl-8-phenylchromen-4-one
Molecular FormulaC19H17NO3
Molecular Weight307.3
XLogP3.1
Topological Polar Surface Area38.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity463
SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
InChI
InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey
CZQHHVNHHHRRDU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
CAS: 154447-36-6
CID: 3973
Formula: C19H17NO3
MW: 307.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight307.3
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass307.12084340
Monoisotopic Mass307.12084340
Topological Polar Surface Area38.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity463
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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