Products for Research Use Only
RegisterLogin

G-1 (LNS 8801)

CAT: 1568-C07357-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1568-C07357-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
881639-98-1
SKU
C07357-1mg
Target
Estrogen/progestogen Receptor
Applications
Endocrinology & Hormones
Smiles
CC (=O) C1=CC2=C (C=C1) NC (C3C2C=CC3) C4=CC5=C (C=C4Br) OCO5
Molecular Formula
C21H18BrNO3
Additionnal Information
G-1 (LNS 8801) is a nonsteroidal and selective agonist of G protein-coupled receptor 30 (GPR30, G protein-coupled estrogen receptor 1, GPER) with Ki of 11 nM.
Storage Conditions
3 years -20°C powder

Chemical Information

rel-1-((3aR,4S,9bS)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone

G-1 is an organic heterotricyclic compound that is 3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline substituted by 6-bromo-1,3-benzodioxol-5-yl and acetyl groups at positions 4 and 8, respectively (the 3aS,4R,9bR-stereoisomer). It is a potent and selective GPER1 agonist (Ki = 11 nM). It has a role as an antineoplastic agent, an antihypertensive agent, a microtubule-destabilising agent, a G-protein-coupled receptor agonist and an anti-obesity agent. It is an organic heterotricyclic compound, an organobromine compound, a benzodioxole, a methyl ketone and an aromatic ketone.

CAS Number881639-98-1
PubChem CID5322399
IUPAC Name1-[(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone
Molecular FormulaC21H18BrNO3
Molecular Weight412.3
XLogP4.6
Topological Polar Surface Area47.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count26
Formal Charge0
Complexity596
SMILES
CC(=O)C1=CC2=C(C=C1)N[C@H]([C@@H]3[C@H]2C=CC3)C4=CC5=C(C=C4Br)OCO5
InChI
InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3/t13-,14+,21-/m1/s1
InChIKey
VHSVKVWHYFBIFJ-HKZYLEAXSA-N
Chemical Structure
2D Structure
2D structure of rel-1-((3aR,4S,9bS)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone
CAS: 881639-98-1
CID: 5322399
Formula: C21H18BrNO3
MW: 412.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight412.3
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass411.04701
Monoisotopic Mass411.04701
Topological Polar Surface Area47.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity596
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
C21549-5mgG-6599
C12767-01G-749
C13212-01G-5555
C13212-25mgG-5555
C13212-5mgG-5555
C04219G-418
C13212-1gG-5555
C13212-100mgG-5555
C12767-25mgG-749
C12526-1gThiamet G

Alternative Products

CatalogName
S0851-1mgG-1 (LNS 8801)
HY-100162-01TOK-8801
A12288-1TOK-8801 1mg
A12288-5TOK-8801 5mg
A12288-100TOK-8801 100mg
A12288-10TOK-8801 10mg
A12288-50TOK-8801 50mg
A12288-25TOK-8801 25mg
1211525LNS-1, 1/4-28 UNF Nut
TL315531SUCLG2 Human shRNA Plasmid Kit (Locus ID 8801)

Popular Products