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Pyr3

CAT: 1568-C03263-04Size: 1 gDry Ice: NoHazardous: No
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CAT#:1568-C03263-04Size:1 g
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CAS Number
1160514-60-2
SKU
C03263-5mg
Target
TRP Channel
Applications
Neuronal Signaling
Additionnal Information
Pyr3 is a selective and potent inhibitor of transient receptor potential canonical channel 3 (TRPC3) . It inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with the IC50 value of 0.7 μM. It holds potential for treating TRPC3-related diseases like cardiac hypertrophy.

Chemical Information

Pyr3
CAS Number1160514-60-2
PubChem CID56964346
IUPAC Nameethyl 1-[4-(2,3,3-trichloroprop-2-enoylamino)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
Molecular FormulaC16H11Cl3F3N3O3
Molecular Weight456.6
XLogP4.8
Topological Polar Surface Area73.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity621
SMILES
CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F
InChI
InChI=1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChIKey
RZHGONNSASQOAY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pyr3
CAS: 1160514-60-2
CID: 56964346
Formula: C16H11Cl3F3N3O3
MW: 456.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.6
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass454.981809
Monoisotopic Mass454.981809
Topological Polar Surface Area73.2 Ų
Heavy Atom Count28
Formal Charge0
Complexity621
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
3751/50Pyr3
A20173-100Pyr3 100mg
A20173-50Pyr3 50mg
A20173-10Pyr3 10mg

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