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BHPI

CAT: 1568-C03235-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C03235-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
56632-39-4
SKU
C03235-5mg
Target
Estrogen/progestogen Receptor
Applications
Endocrinology & Hormones
Additionnal Information
BHPI is a potent noncompetitive inhibitor of estrogen receptor α (ERα), which disrupts the protective estrogen–ERα-mediated activation of the unfolded protein response (UPR), leading to sustained UPR activation. It specifically inhibits the growth of drug-resistant ERα-positive breast and ovarian cancer cells and induces significant tumor regression in a mouse xenograft model of breast cancer.

Chemical Information

3,3-bis(4-hydroxyphenyl)-7-methyl-1,3-dihydro-2H-indol-2-one

an estrogen receptor alpha inhibitor

CAS Number56632-39-4
PubChem CID3860640
IUPAC Name3,3-bis(4-hydroxyphenyl)-7-methyl-1H-indol-2-one
Molecular FormulaC21H17NO3
Molecular Weight331.4
XLogP3.6
Topological Polar Surface Area69.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity469
SMILES
CC1=C2C(=CC=C1)C(C(=O)N2)(C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
InChI
InChI=1S/C21H17NO3/c1-13-3-2-4-18-19(13)22-20(25)21(18,14-5-9-16(23)10-6-14)15-7-11-17(24)12-8-15/h2-12,23-24H,1H3,(H,22,25)
InChIKey
FABLAHMQSQFDHR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3,3-bis(4-hydroxyphenyl)-7-methyl-1,3-dihydro-2H-indol-2-one
CAS: 56632-39-4
CID: 3860640
Formula: C21H17NO3
MW: 331.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.4
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass331.12084340
Monoisotopic Mass331.12084340
Topological Polar Surface Area69.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity469
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS131261-01BHPI
6116/50BHPI 50 mg
6116/10BHPI 10 mg

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