AD-8007

CAT: 1568-C01960-04Size: 1 gDry Ice: NoHazardous: No

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CAT#:1568-C01960-04Size:1 g

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CAS Number

1497439-74-3

SKU

C01960-5mg

Target

ACSS2

Applications

Metabolism

Additionnal Information

AD-8007 is a selective and brain-penetrant inhibitor of acetyl CoA synthase 2 (ACSS2) . AD-8007 significantly reduces lipid storage, cell colony formation, acetyl-CoA levels and cell survival in vitro models, and increase tumor cell death, tumor burden and increases survival in in-vivo models. AD-8007 exhibits anti-cancer activity.

Chemical Information

(2S)-2-amino-2-cyclopropyl-1-(3,3-diphenylpiperidin-1-yl)ethanone

CAS Number	1497439-74-3
PubChem CID	72937507
IUPAC Name	(2S)-2-amino-2-cyclopropyl-1-(3,3-diphenylpiperidin-1-yl)ethanone
Molecular Formula	C22H26N2O
Molecular Weight	334.5
XLogP	3.5
Topological Polar Surface Area	46.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Heavy Atom Count	25
Formal Charge	0
Complexity	443

SMILES

C1CC(CN(C1)C(=O)[C@H](C2CC2)N)(C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChI=1S/C22H26N2O/c23-20(17-12-13-17)21(25)24-15-7-14-22(16-24,18-8-3-1-4-9-18)19-10-5-2-6-11-19/h1-6,8-11,17,20H,7,12-16,23H2/t20-/m0/s1

InChIKey

RVDAHWSYHUHTAL-FQEVSTJZSA-N

Chemical Structure

2D Structure

CAS: 1497439-74-3

CID: 72937507

Formula: C22H26N2O

MW: 334.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	334.5
XLogP3	3.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	334.204513457
Monoisotopic Mass	334.204513457
Topological Polar Surface Area	46.3 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	443
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
E1930-100mg	AD-8007
HY-P990549-01	ASK-8007
GTR19274360-01	FM-8007
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M30749	AD 01
VFA60069	AD 0261
HY-121058	AD 4743
HY-119034	AD-20
HY-124134	AD-2646
T70484-01	AD-35

AD-8007

Chemical Information

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