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PRT543

CAT: 1568-C01787-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1568-C01787-02Size:25 mg
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CAS Number
1989620-03-2
SKU
C01787-5mg
Target
PRMT
Applications
Epigenetics
Additionnal Information
PRT543 is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) with broad antitumor activity in vitro and in vivo. It also inhibits the methyltransferase activity of the PRMT5/MEP50 complex with an IC50 of 10.8 nM.

Chemical Information

7-[(5R)-5-C-(4-Chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS Number1989620-03-2
PubChem CID122497020
IUPAC Name(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-(4-chlorophenyl)-hydroxymethyl]oxolane-3,4-diol
Molecular FormulaC17H17ClN4O4
Molecular Weight376.8
XLogP0.8
Topological Polar Surface Area127
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity495
SMILES
C1=CC(=CC=C1[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O)O)Cl
InChI
InChI=1S/C17H17ClN4O4/c18-9-3-1-8(2-4-9)11(23)14-12(24)13(25)17(26-14)22-6-5-10-15(19)20-7-21-16(10)22/h1-7,11-14,17,23-25H,(H2,19,20,21)/t11-,12+,13-,14-,17-/m1/s1
InChIKey
ITEKIFMGFZAFPM-QFRSUPTLSA-N
Chemical Structure
2D Structure
2D structure of 7-[(5R)-5-C-(4-Chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS: 1989620-03-2
CID: 122497020
Formula: C17H17ClN4O4
MW: 376.8
Interactive 3D Structure
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Computed Properties
PropertyValue
Molecular Weight376.8
XLogP30.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass376.0938327
Monoisotopic Mass376.0938327
Topological Polar Surface Area127 Ų
Heavy Atom Count26
Formal Charge0
Complexity495
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19232802PRT543
A24356-10PRT543 (PRMT5-IN-35) 10mg
A24356-50PRT543 (PRMT5-IN-35) 50mg
A24356-100PRT543 (PRMT5-IN-35) 100mg
A24356-5PRT543 (PRMT5-IN-35) 5mg

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