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Senicapoc (ICA-17043)

CAT: 1568-C01279-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C01279-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
289656-45-7
SKU
C01279-5mg
Target
Potassium Channel
Applications
Transmembrane Transporters
Smiles
NC (=O) C (C1=CC=CC=C1) (C2=CC=C (F) C=C2) C3=CC=C (F) C=C3
Additionnal Information
Senicapoc (ICA-17043) is a Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM and produces dose-dependent increases in hemoglobin and decreases in markers of hemolysis. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
Storage Conditions
3 years -20°C powder

Chemical Information

Senicapoc

Senicapoc is an orally bioavailable inhibitor of the calcium-activated potassium channel KCa3.1 (Gardos channel; KCNN4; IK-1; SK4), with potential anti-inflammatory and immunomodulatory activities. Upon oral administration, senicapoc targets, binds to and inhibits KCa3.1.

CAS Number289656-45-7
PubChem CID216327
IUPAC Name2,2-bis(4-fluorophenyl)-2-phenylacetamide
Molecular FormulaC20H15F2NO
Molecular Weight323.3
XLogP4.1
Topological Polar Surface Area43.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity397
SMILES
C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
InChI
InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChIKey
SCTZUZTYRMOMKT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Senicapoc
CAS: 289656-45-7
CID: 216327
Formula: C20H15F2NO
MW: 323.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.3
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass323.11217043
Monoisotopic Mass323.11217043
Topological Polar Surface Area43.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS386855-01Senicapoc (ICA-17043)
A11568-50Senicapoc (ICA-17043) 50mg
A11568-10Senicapoc (ICA-17043) 10mg
A11568-5Senicapoc (ICA-17043) 5mg
A11568-200Senicapoc (ICA-17043) 200mg
A11568-100Senicapoc (ICA-17043) 100mg
A11568-25Senicapoc (ICA-17043) 25mg
A11568-10mM-DSenicapoc (ICA-17043) 10mM * 1mL in DMSO
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