TP-008
CAT:
804-HY-125851-04
Size:
100 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TP-008
- CAS Number: 1976038-41-1
- UNSPSC Description: TP-008 is a potent, selective and orally active (Activin-Like Kinase 5) ALK5 inhibitor with pIC50 and pEC50 values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose[1].
- Target Antigen: TGF-β Receptor
- Type: Reference compound
- Related Pathways: TGF-beta/Smad
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/tgfβri-in-2.html
- Purity: 99.42
- Solubility: DMSO : 9.6 mg/mL (ultrasonic;warming)
- Smiles: O=C(N)CN(C1=C2C=CN=C1)C(N2C3=CC(C4=CC(Cl)=CC=C4F)=NC=C3C)=O
- Molecular Weight: 411.82
- References & Citations: [1]Wang H, et al. Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.Bioorg Med Chem Lett. 2016 Sep 1;26(17):4334-9.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported