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Methazolamide-d6

CAT: 0804-HY-B0553S-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0553S-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methazolamide-d6 is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders[1][2].
CAS Number
1795142-30-1
Product Name Alternative
L584601-d6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Carbonic Anhydrase; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C(/N=C1SC(S(N)(=O)=O)=NN\1C([2H])([2H])[2H])=O
Molecular Formula
C5H2D6N4O3S2
Molecular Weight
242.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Yang F, et al. HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese. Pharmacogenomics J. 2016;16 (1) :83-87.|[3]Abbate F, et al. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors. J Enzyme Inhib Med Chem. 2003;18 (4) :303-308.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CA II

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