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Methazolamide (Standard)

CAT: 0804-HY-B0553R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0553R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methazolamide (Standard) is the analytical standard of Methazolamide. This product is intended for research and analytical applications. Methazolamide (L584601) is a BBB-penetrable and orally active carbonic anhydrase inhibitor, with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage[1][2].
CAS Number
554-57-4
Product Name Alternative
L584601 (Standard)
UNSPSC
12352005
Target
Apoptosis; Carbonic Anhydrase; Caspase; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/methazolamide-standard.html
Smiles
CC(/N=C1SC(S(=O)(N)=O)=NN/1C)=O
Molecular Formula
C5H8N4O3S2
Molecular Weight
236.27
References & Citations
[1]Yang F, et al. HLA-B*59:01: a marker for Stevens-Johnson syndrome/toxic epidermal necrolysis caused by methazolamide in Han Chinese. Pharmacogenomics J. 2016;16 (1) :83-87.|[2]Abbate F, et al. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the perfluorobenzoyl analogue of methazolamide. Implications for the drug design of fluorinated inhibitors. J Enzyme Inhib Med Chem. 2003;18 (4) :303-308.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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