Briciclib disodium salt 5mg

CAT: 0628-A13649-5Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0628-A13649-5Size:5 mg

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CAS Number

865784-01-6

Chemical Information

Briciclib Sodium

Briciclib Sodium is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis.

CAS Number	865784-01-6
PubChem CID	24754472
IUPAC Name	disodium;[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] phosphate
Molecular Formula	C19H21Na2O10PS
Molecular Weight	518.4
Topological Polar Surface Area	152
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Heavy Atom Count	33
Formal Charge	0
Complexity	705

SMILES

COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]

InChI

InChI=1S/C19H23O10PS.2Na/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22;;/h5-11H,12H2,1-4H3,(H2,20,21,22);;/q;2*+1/p-2/b8-7+;;

InChIKey

MIBWXNAYNGADJD-MIIBGCIDSA-L

Chemical Structure

2D Structure

CAS: 865784-01-6

CID: 24754472

Formula: C19H21Na2O10PS

MW: 518.4

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	518.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Exact Mass	518.03884360
Monoisotopic Mass	518.03884360
Topological Polar Surface Area	152 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	705
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	3
Compound Is Canonicalized	Yes

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Briciclib disodium salt 5mg

Chemical Information

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