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GSK-923295 2mg

CAT: 0628-A11435-2Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0628-A11435-2Size:2 mg
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CAS Number
1088965-37-0

Chemical Information

Gsk-923295a

GSK-923295 is an imidazopyridine that is imidazo[1,2-a]pyridine substituted by 4-{(2S)-2-[3-chloro-4-(propan-2-yloxy)benzamido]-3-[(N,N-dimethylglycyl)amino]propyl}phenyl, and (1S)-1-hydroxyethyl groups at positions 2 and 8, respectively. It is an allosteric inhibitor of centromere-associated protein-E (CENP-E) kinesin motor ATPase activity (Ki = 3.2 nM and 1.6 nM for human and canine CENP-E motordomains, respectively). It has a role as a centromere protein E inhibitor, an antineoplastic agent and an antimitotic. It is a secondary carboxamide, a member of benzamides, an aromatic ether, a secondary alcohol, an imidazopyridine, a tertiary amino compound and a member of monochlorobenzenes.

CAS Number1088965-37-0
PubChem CID46898058
IUPAC Name3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide
Molecular FormulaC32H38ClN5O4
Molecular Weight592.1
XLogP5
Topological Polar Surface Area108
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count12
Heavy Atom Count42
Formal Charge0
Complexity870
SMILES
C[C@@H](C1=CC=CN2C1=NC(=C2)C3=CC=C(C=C3)C[C@@H](CNC(=O)CN(C)C)NC(=O)C4=CC(=C(C=C4)OC(C)C)Cl)O
InChI
InChI=1S/C32H38ClN5O4/c1-20(2)42-29-13-12-24(16-27(29)33)32(41)35-25(17-34-30(40)19-37(4)5)15-22-8-10-23(11-9-22)28-18-38-14-6-7-26(21(3)39)31(38)36-28/h6-14,16,18,20-21,25,39H,15,17,19H2,1-5H3,(H,34,40)(H,35,41)/t21-,25-/m0/s1
InChIKey
WHMXDBPHBVLYRC-OFVILXPXSA-N
Chemical Structure
2D Structure
2D structure of Gsk-923295a
CAS: 1088965-37-0
CID: 46898058
Formula: C32H38ClN5O4
MW: 592.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight592.1
XLogP35
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count12
Exact Mass591.2612324
Monoisotopic Mass591.2612324
Topological Polar Surface Area108 Ų
Heavy Atom Count42
Formal Charge0
Complexity870
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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