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IZTZ-1

CAT: 0804-HY-147973-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147973-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].
CAS Number
2636771-45-2
UNSPSC
12352005
Target
Apoptosis; c-Myc
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iztz-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=CC=C(C3=C(C4=CC=C(N5CCN(C)CC5)C=C4)N=C(C6=NC7=CC=CC=C7S6)N3)C=C2)CC1
Molecular Formula
C32H35N7S
Molecular Weight
549.73
References & Citations
[1]Wu TY, et al. A drug-like imidazole-benzothiazole conjugate inhibits malignant melanoma by stabilizing the c-MYC G-quadruplex. Bioorg Chem. 2020 Jun;99:103866.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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