Recombinant Dog Haptoglobin (HP)

CAT: 0399-CSB-EP010691DO-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0399-CSB-EP010691DO-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Abbreviation

Recombinant Dog HP protein

Gene Name

UniProt

P19006

Expression Region

1-329aa

Organism

Canis lupus familiaris (Dog) (Canis familiaris)

Target Sequence

EDTGSEATNNTEVSLPKPPVIENGYVEHMIRYQCKPFYKLHTEGDGVYTLNSEKHWTNKAVGEKLPECEAVCGKPKNPVDQVQRIMGGSVDAKGSFPWQAKMVSHHNLTSGATLINEQWLLTTAKNLFLGHKDDAKANDIAPTLKLYVGKNQLVEVEKVVLHPDYSKVDIGLIKLKQKVPIDERVMPICLPSKDYAEVGRIGYVSGWGRNSNFNFTELLKYVMLPVADQDKCVQHYEGSTVPEKKSPKSPVGVQPILNEHTFCAGMSKFQEDTCYGDAGSAFAVHDQDEDTWYAAGILSFDKSCTVAEYGVYVKVPSVLAWVQETIAGN

Tag

C-terminal 6xHis-tagged

Type

Developed Protein

Source

E.coli

Field of Research

Others

Relevance

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway

Purity

Greater than 85% as determined by SDS-PAGE.

Activity

Not Test

Form

Liquid or Lyophilized powder

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.261.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Molecular Weight

43.4 kDa

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Protein Length

Full Length

UniProtKB · P19006

Haptoglobin

HPT_CANLF · Canis lupus familiaris

View on UniProt ↗

Primary accession: P19006
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: HP
Protein existence: 1: Evidence at protein level
Organism: Canis lupus familiaris (Dog)
Taxonomy ID: 9615
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q9TRH6, Q9TRH7

Protein keywords

Biological process

Acute phaseImmunity

Molecular function

AntibioticAntimicrobialAntioxidantSerine protease homolog

Technical term

Direct protein sequencingReference proteome

PTM

Disulfide bondGlycoprotein

Ligand

Hemoglobin-binding

Cellular component

Secreted

Domain

Sushi

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