O-linked GlcNAc Transferase Substrate

• Description:

  O-linked GlcNAc Transferase Substrate_x000D_ Catalog number: B2011466_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 1 mg_x000D_ Molecular Weight or Concentration: 1783.2 g/mol_x000D_ Supplied as: Lyophilized_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: -20 °C_x000D_ Keywords: OGT Substrate_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Makwana V, Ryan P, Malde AK, Anoopkumar-Dukie S, Rudrawar S. Bisubstrate Ether-Linked Uridine-Peptide Conjugates as O-GlcNAc Transferase Inhibitors ChemMedChem. 2021 Feb 4;16(3):477-483._x000D_ 2: Chang YH, Weng CL, Lin KI. O-GlcNAcylation and its role in the immune system J Biomed Sci. 2020 Apr 29;27(1):57._x000D_ 3: Petrus P, Lecoutre S, Dollet L, Wiel C, Sulen A, Gao H, Tavira B, Laurencikiene J, Rooyackers O, Checa A, Douagi I, Wheelock CE, Arner P, McCarthy M, Bergo MO, Edgar L, Choudhury RP, Aouadi M, Krook A, Rydén M. Glutamine Links Obesity to Inflammation in Human White Adipose Tissue Cell Metab. 2020 Feb 4;31(2):375-390.e11._x000D_ 4: Chatham JC, Young ME, Zhang J. Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications Curr Opin Pharmacol. 2021 Apr;57:1-12._x000D_ 5: Kositzke A, Fan D, Wang A, Li H, Worth M, Jiang J. Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe Int J Biol Macromol. 2021 Feb 1;169:51-59._x000D_ 6: Rafie K, Raimi O, Ferenbach AT, Borodkin VS, Kapuria V, van Aalten DMF. Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats Open Biol. 2017 Jun;7(6):170078._x000D_ 7: Pereira Sena P, Weber JJ, Watchon M, Robinson KJ, Wassouf Z, Hauser S, Helm J, Abeditashi M, Schmidt J, Hübener-Schmid J, Schöls L, Laird AS, Riess O, Schmidt T. Pathophysiological interplay between O-GlcNAc transferase and the Machado-Joseph disease protein ataxin-3 Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2025810118._x000D_ 8: Willems AP, Gundogdu M, Kempers MJE, Giltay JC, Pfundt R, Elferink M, Loza BF, Fuijkschot J, Ferenbach AT, van Gassen KLI, van Aalten DMF, Lefeber DJ. Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability J Biol Chem. 2017 Jul 28;292(30):12621-12631._x000D_ 9: Hu CW, Worth M, Fan D, Li B, Li H, Lu L, Zhong X, Lin Z, Wei L, Ge Y, Li L, Jiang J. Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase Nat Chem Biol. 2017 Dec;13(12):1267-1273._x000D_ 10: Liu L, Li L, Ma C, Shi Y, Liu C, Xiao Z, Zhang Y, Tian F, Gao Y, Zhang J, Ying W, Wang PG, Zhang L. O-GlcNAcylation of Thr(12)/Ser(56) in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity J Biol Chem. 2019 Nov 8;294(45):16620-16633. _x000D_ _x000D_ Products Related to O-linked GlcNAc Transferase Substrate can be found at Substrates

• Short Description:

  Catalog Number: B2011466 (1 mg)_x000D_ O-linked GlcNAc Transferase Substrate is a high quality peptide substrate for O-linked GlcNAc transferase (OGT). This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5