M8-B
CAT:
804-HY-110181-06
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
M8-B
- CAS Number: 883976-12-3
- UNSPSC Description: M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb)[1].
- Target Antigen: TRP Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/m8-b.html
- Purity: 99.89
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: COC(C=C(CN(CCN)C(C1=CC=CS1)=O)C=C2)=C2OCC3=CC=CC=C3.Cl
- Molecular Weight: 432.96
- References & Citations: [1]Almeida MC, et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32(6):2086-99.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported