M8-B

• UNSPSC Description:

  M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb)[1].

• Target Antigen:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/m8-b.html

• Purity:

  99.89

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  COC(C=C(CN(CCN)C(C1=CC=CS1)=O)C=C2)=C2OCC3=CC=CC=C3.Cl

• Molecular Weight:

  432.96

• References & Citations:

  [1]Almeida MC, et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32(6):2086-99.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  883976-12-3