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UCD38B (hydrochloride)

CAT: 0804-HY-117359-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117359-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF) . UCD38B hydrochloride induces apoptosis[1][2].
CAS Number
1115177-19-9
Product Name Alternative
γDGG; γ-D-Glutamylglycine, γDGG (acetate); γ-D-Glutamylglycine (acetate)
UNSPSC
12352005
Target
Apoptosis; PAI-1
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ucd38b-hydrochloride.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CNC1=C(Cl)N=C(C(NC(N)=N)=O)C(N)=N1)OCC2=CC=CC=C2.Cl.[x]
Molecular Formula
C15H16ClN7O3.xHCl
References & Citations
[1]Pasupuleti N, et, al. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344 (3) :600-15.|[2]Leon LJ, et, al. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8 (4) :e63038.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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