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RG7112

CAT: 0804-HY-10959-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10959-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RG7112 is a potent, selective, first clinical, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2[1].
CAS Number
939981-39-2
Product Name Alternative
RO5045337
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E1/E2/E3 Enzyme; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RG7112.html
Purity
99.91
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
C[C@@]1([C@](C)(N(C(C2=CC=C(C=C2OCC)C(C)(C)C)=N1)C(N3CCN(CC3)CCCS(=O)(C)=O)=O)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Molecular Formula
C38H48Cl2N4O4S
Molecular Weight
727.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Vu B, et al. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett. 2013 Apr 2;4 (5) :466-9.|[2]Tovar C, et al. MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models. Cancer Res. 2013 Apr 15;73 (8) :2587-97.|[3]Verreault M, et al. Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas. Clin Cancer Res. 2016 Mar 1;22 (5) :1185-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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CatalogName
MBS131293RG7112
A11523-50RG7112 50mg
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A11523-500RG7112 500mg
A11523-25RG7112 25mg
A11523-10RG7112 10mg
A11523-5RG7112 5mg
A11523-2RG7112 2mg
A11523-1RG7112 1mg
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