ENTK (light chain, Cleaved-Ile785) rabbit pAb

ENTK (light chain, Cleaved-Ile785) rabbit pAb

• Description: Catalytic activity: Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond. Disease: Defects in PRSS7 are a cause of enterokinase deficiency [MIM: 226200]; a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. function: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. PTM: The chains are derived from a single precursor that is cleaved by a trypsin-like protease. similarity: Belongs to the peptidase S1 family. similarity: Contains 1 MAM domain. similarity: Contains 1 peptidase S1 domain. similarity: Contains 1 SEA domain. similarity: Contains 1 SRCR domain. similarity: Contains 2 CUB domains. similarity: Contains 2 LDL-receptor class A domains. subunit: Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond. tissue specificity: Intestinal brush border.
• Synonyms: Enteropeptidase (EC 3.4.21.9;Enterokinase;Serine protease 7;Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]
• Gene ID: 5651
• UniProt: P98073
• Cellular Locus: Membrane ; Single-pass type II membrane protein.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthesized peptide derived from human ENTK (light chain, Cleaved-Ile785)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:1000-2000 ELISA 1:5000-20000
• Molecular Weight: 26kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.