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OTS193320

CAT: 0804-HY-122182-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122182-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX[1].
CAS Number
2093401-33-1
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ots193320.html
Purity
99.08
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[N+](C1=CC=C(CN[C@@H]2CC[C@H](NC3=CC4=NC(C5=CC(Cl)=C(OC)C=C5OC)=CN4C=C3)CC2)C=C1)[O-]
Molecular Formula
C28H30ClN5O4
Molecular Weight
536.02
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Theodore Vougiouklakis, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9 (61) :31820-31831.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SUV39H2/KMT1B

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CatalogName
M13286-01OTS193320

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