MK-0812 (Succinate)
CAT:
804-HY-50669A-03
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MK-0812 (Succinate)
- CAS Number: 851916-42-2
- UNSPSC Description: MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2.
- Target Antigen: CCR
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Endocrinology
- Assay Protocol: https://www.medchemexpress.com/MK-0812-Succinate.html
- Purity: 99.90
- Solubility: DMSO : ≥ 32 mg/mL
- Smiles: O=C([C@]1(C(C)C)C[C@H](N[C@H]2CCOC[C@H]2OC)CC1)N3CCC(N=CC(C(F)(F)F)=C4)=C4C3.O=C(O)CCC(O)=O
- Molecular Weight: 587.63
- References & Citations: [1]Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.|[2]Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352(1-2):101-10.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 2