Tubulin polymerization/V-ATPase-IN-1

Tubulin polymerization/V-ATPase-IN-1

• UNSPSC Description: Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a Tubulin polymerization/V-ATPase inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration[1].
• Target Antigen: Apoptosis; Microtubule/Tubulin; Proton Pump
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Membrane Transporter/Ion Channel
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-v-atpase-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: COC(C(Cl)=CC(C1=NC(C(N)=O)=CC2=C1C=C3C(OCCO3)=C2)=C4)=C4OC
• Molecular Weight: 400.81
• References & Citations: [1]Leng J, et al. Discovery of Novel Isoquinoline Analogues as Dual Tubulin Polymerization/V-ATPase Inhibitors with Immunogenic Cell Death Induction. J Med Chem. 2024 Feb 22;67(4):3144-3166.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported