HA15 (Standard)

CAT: 0804-HY-100437RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100437RSize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HA15 (Standard) is the analytical standard of HA15 (HY-100437) . This product is intended for research and analytical applications. HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity[1].
CAS Number
[1609402-14-3]
Target
Apoptosis; Autophagy; HSP; Reference Standards
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
CC(NC1=NC(C2=CC=CC(NS(=O)(C3=C4C=CC=C(N(C)C)C4=CC=C3)=O)=C2)=CS1)=O
Molecular Formula
C23H22N4O3S2
Molecular Weight
466.58
References & Citations
[1]Cerezo M et al. Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance. Cancer Cell. 2016 Jun 13;29 (6) :805-19.|[2]Ruggiero C, et al. The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathways. Mol Cell Endocrinol. 2018 Oct 15;474:57-64.|[3]Duo Xu, et al. Endoplasmic Reticulum Stress Signaling as a Therapeutic Target in Malignant Pleural Mesothelioma. Cancers (Basel) . 2019 Oct; 11 (10) : 1502.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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T6855-01HA15
A16128-5HA15 5mg
A16128-50HA15 50mg
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A16128-1HA15 1mg
A16128-2HA15 2mg
A16128-100HA15 100mg
A16128-10HA15 10mg
A16128-25HA15 25mg
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