β-CGRP, human (TFA)

• Description :

  β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells[1].

• Product Name Alternative :

  Human β-CGRP (TFA) ; CGRP-II (Human) (TFA)

• UNSPSC :

  12352209

• Target :

  CGRP Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/_beta_-CGRP,_human_TFA.html

• Purity :

  99.57

• Solubility :

  H2O : 100 mg/mL (ultrasonic)

• Smiles :

  [ACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAF-NH2(Disulfidebridge:Cys2-Cys7)(TFAsalt)]

• Molecular Formula :

  C162H267N51O48S3.xC2HF3O2

• Molecular Weight :

  3793.41 (free base)

• References & Citations :

  [1]McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393 (6683) :333-9.|[2]Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94 (4) :1099-142.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported