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Vitexin B-1

CAT: 0804-HY-N2741Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N2741Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vitexin B-1 is an inhibitor of Bcl-2 and the agonist of Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC50s of 3.2, 2.1, 1.8 and 0.39 μM, respectively[1].
CAS Number
357645-16-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bcl-2 Family
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vitexin-b-1.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](C2=CC(OC)=C(O)C=C2)C3=CC(O)=C(OC)C=C3C=C1C=O
Molecular Formula
C20H20O6
Molecular Weight
356.37
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Zhou Y, et al. Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res. 2009 Aug 15;15 (16) :5161-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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