alpha-1,3-Galactosyltransferase (a1,3GalT)

• UNSPSC Description:

  alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species[1].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Enzyme

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/alpha-1-3-galactosyltransferase-a1-3galt.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [alpha-1,3-Galactosyltransferase(a1,3GalT)]

• References & Citations:

  [1]Sumnima Singh, et al. Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. Cell Host Microbe. 2021 Mar 10;29(3):347-361.e12.|[2]Anne-Laure Turcot-Dubois, et al. Long-term evolution of the CAZY glycosyltransferase 6 (ABO) gene family from fishes to mammals--a birth-and-death evolution model. Glycobiology. 2007 May;17(5):516-28.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  Store at -80°C for 2 years

• Clinical Information:

  No Development Reported

• CAS Number:

  128449-51-4