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Infigratinib-d3

CAT: 0804-HY-13311S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13311S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively[1].
Product Name Alternative
BGJ-398-d3; NVP-BGJ398-d3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
FGFR
Type
Isotope-Labeled Compounds
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.90
Solubility
DMSO : 12 mg/mL (ultrasonic; warming)
Smiles
CCN1CCN(C2=CC=C(NC3=NC=NC(N(C([2H])([2H])[2H])C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)=C3)C=C2)CC1
Molecular Formula
C26H28D3Cl2N7O3
Molecular Weight
563.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Guagnano V, et al. Discovery of 3- (2,6-Dichloro-3,5-dimethoxy-phenyl) -1-{6-[4- (4-ethyl-piperazin-1-yl) -phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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