Infigratinib (Standard)

• Description:

  Infigratinib (Standard) is the analytical standard of Infigratinib. This product is intended for research and analytical applications. Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

• UNSPSC:

  12352100

• Target:

  Apoptosis; FGFR; Reference Standards

• Related Pathways:

  Apoptosis; Others; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  ClC1=C (C (Cl) =C (C=C1OC) OC) NC (N (C2=CC (NC3=CC=C (C=C3) N4CCN (CC4) CC) =NC=N2) C) =O

• Molecular Formula:

  C26H31Cl2N7O3

• Molecular Weight:

  560.48

• References & Citations:

  [1]Guagnano V, et al. Discovery of 3- (2,6-Dichloro-3,5-dimethoxy-phenyl) -1-{6-[4- (4-ethyl-piperazin-1-yl) -phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T|[2]Konecny GE, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12 (5) :632-42.|[3]Liu H, et al. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discov. 2018 Mar;8 (3) :354-369.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  872511-34-7