SPR741 (acetate)

CAT: 0804-HY-P1649B-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-P1649B-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 acetate increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 acetate inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 acetate[1][2].

Product Name Alternative

NAB741 (acetate)

UNSPSC

12352209

Target

Antibiotic; Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/spr741-acetate.html

Purity

99.44

Solubility

DMSO : 130 mg/mL (ultrasonic)

Smiles

CC(N[C@@H]([C@H](O)C)C(N[C@H](CO)C(N[C@@H](CCNC([C@](N1)([H])[C@H](O)C)=O)C(N[C@@H](CCN)C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCN)C1=O)=O)CCN)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O.CC(O)=O

Molecular Formula

C46H77N13O15

Molecular Weight

1052.18

References & Citations

[1]Eckburg PB, et al. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects. Antimicrob Agents Chemother. 2019 Aug 23;63 (9) . pii: e00892-19.|[2]Corbett D, et al. Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741. Antimicrob Agents Chemother. 2017 Jul 25;61 (8) . pii: e00200-17.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

Phase 1

Citation 01

J Pharm Biomed Anal. 2024 Aug 6:250:116403.|Nature. 2022 Apr;604 (7906) :541-545.|Int J Antimicrob Agents. 2021 Nov;58 (5) :106434.

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