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Emodin-8-glucoside

CAT: 0804-HY-N0311-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0311-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier[1][2][3][4][5].
CAS Number
23313-21-5
UNSPSC
12352005
Hazard Statement
H302
Target
Aldose Reductase; p38 MAPK; SOD; Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/emodin-8-glucoside.html
Purity
99.35
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C13)=O
Molecular Formula
C21H20O10
Molecular Weight
432.38
Precautions
H302
References & Citations
[1]Kim J M, et al. Constituents of the fruits of Rumex japonicus with Inhibitory Activity on Aldose Reductase[J]. Journal of Applied Biological Chemistry, 2008, 51 (1) : 13-16.|[2]Hwangbo K, et al., Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica. Arch Pharm Res. 2012 Sep;35 (9) :1583-9.|[3]Wang C, et al., Neuroprotective effects of emodin-8-O-beta-D-glucoside in vivo and in vitro. Eur J Pharmacol. 2007 Dec 22;577 (1-3) :58-63.|[4]Zhang K, et al., Discovery of Natural Products Alleviating Renal Fibrosis with a Viscosity-Responsive Molecular Probe. Anal Chem. 2024 Apr 23;96 (16) :6356-6365.|[5]Vaziri-Amjad S, et al., Natural anthraquinones as promising MAPK3 inhibitors for complementary cancer therapy[J]. Journal of Chemistry, 2023, 2023 (1) : 6683470.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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