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Recombinant Human Endostatin

CAT: 0355-AP60040Size: InquireDry Ice: NoHazardous: No
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Background
Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family. Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
Gene ID
80781
UniProt
P39060
Target
HSHRDFQPVL HLVALNSPLS GGMRGIRGAD FQCFQQARAV GLAGTFRAFL SSRLQDLYSI VRRADRAAVP IVNLKDELLF PSWEALFSGS EGPLKPGARI FSFDGKDVLR HPTWPQKSVW HGSDPNGRRL TESYCETWRT EAPSATGQAS SLLGGRLLGQ SAASCHHAYI VLCIENSFMT ASK
Purification
> 96 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rHuEndostatin as determined by LAL method.
Bioactivity
Fully biologically active when compared to standard. The ED50 as determined by inhibiting the FGF basic-dependent proliferation of HUVEC migration is less than 2.0 μg/mL in the presence of Anti-Human Endostatin Polyclonal Antibody.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 20.1 kDa, a single non-glycosylated polypeptide chain containing 183 amino acids (C-terminal fragment of Collagen alpha-1 (XVIII) chain) .
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Host or Source
Escherichia coli

UniProtKB · P39060

Collagen alpha-1(XVIII) chain

COIA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P39060
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
COL18A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8MVI4, Q58EX6, Q6RZ39, Q6RZ40, Q6RZ41, Q8N4S4, Q8WXI5, Q96T70, Q9UK38, Q9Y6Q7, Q9Y6Q8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageAlternative splicing

Cellular component

Basement membraneExtracellular matrixSecreted

Biological process

Cell adhesion

Domain

CollagenRepeatSignal

PTM

Disulfide bondGlycoproteinHydroxylationPhosphoproteinProteoglycan

Disease

Glaucoma

Ligand

Metal-bindingZinc

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