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Parmodulin 2

CAT: 0804-HY-13965-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13965-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM[1]. Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo[2].
CAS Number
423735-93-7
Product Name Alternative
ML161
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/parmodulin-2.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(NC(CCC)=O)=C1)C2=CC=CC=C2Br
Molecular Formula
C17H17BrN2O2
Molecular Weight
361.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Gandhi DM, et al. Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells. Bioorg Med Chem. 2018 May 15;26 (9) :2514-2529.|[2]Susanna F Gunnink, et al. Allosteric inhibition of protease activated receptor 1: a new antiplatelet therapy.|[3]Aisiku O, et al. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood. 2015 Mar 19;125 (12) :1976-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR1

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Alternative Products

CatalogName
T1893-01Parmodulin 2
C17145-50mgML161 (Parmodulin 2)

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