SPSB2-iNOS inhibitory cyclic peptide-2

• UNSPSC Description:

  SPSB2-iNOS inhibitory cyclic peptide-2 (Compound CP2) is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 is reduction-resistant and oxidatively stable[1].

• Target Antigen:

  NO Synthase

• Type:

  Peptides

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/spsb2-inos-inhibitory-cyclic-peptide-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCC(N1)=O)=O)CC(N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)([H])[C@@H](C)CC)=O)CC(O)=O)[C@@H]1CC2=CNC3=CC=CC=C23

• Molecular Weight:

  827.84

• References & Citations:

  [1]Yap BK, et al., Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction. FEBS Lett. 2016 Mar;590(6):696-704.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1989528-33-7