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CKK-E12

CAT: 0804-HY-134781-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134781-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo
CAS Number
1432494-65-9
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ckk-e12.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)N1)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O
Molecular Formula
C60H120N4O6
Molecular Weight
993.62
Precautions
H315, H319, H320
References & Citations
[1]Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111 (15) :5753]. Proc Natl Acad Sci U S A. 2014;111 (11) :3955-3960. |[2]Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17 (3) :1326-1335. |[3]Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17 (3) :310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

Chemical Information

3,6-Bis(4-(bis(2-hydroxydodecyl)amino)butyl)piperazine-2,5-dione
CAS Number1432494-65-9
PubChem CID71555845
IUPAC Name3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]piperazine-2,5-dione
Molecular FormulaC60H120N4O6
Molecular Weight993.6
XLogP18.7
Topological Polar Surface Area146
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count8
Rotatable Bond Count54
Heavy Atom Count70
Formal Charge0
Complexity1010
SMILES
CCCCCCCCCCC(CN(CCCCC1C(=O)NC(C(=O)N1)CCCCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)O
InChI
InChI=1S/C60H120N4O6/c1-5-9-13-17-21-25-29-33-41-53(65)49-63(50-54(66)42-34-30-26-22-18-14-10-6-2)47-39-37-45-57-59(69)62-58(60(70)61-57)46-38-40-48-64(51-55(67)43-35-31-27-23-19-15-11-7-3)52-56(68)44-36-32-28-24-20-16-12-8-4/h53-58,65-68H,5-52H2,1-4H3,(H,61,70)(H,62,69)
InChIKey
ZISVTYVLWSZJAL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3,6-Bis(4-(bis(2-hydroxydodecyl)amino)butyl)piperazine-2,5-dione
CAS: 1432494-65-9
CID: 71555845
Formula: C60H120N4O6
MW: 993.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight993.6
XLogP318.7
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count8
Rotatable Bond Count54
Exact Mass992.92078756
Monoisotopic Mass992.92078756
Topological Polar Surface Area146 Ų
Heavy Atom Count70
Formal Charge0
Complexity1010
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count6
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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